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For greater results that would include more pronounced muscle gain and fat loss, more frequent injections would be required above the three times per day protocolfound in the present study. In this study, we used the low dose, high frequency (20 mg) injection, but the doses used in other studies were higher at 80 mg per day and 40 mg per day. The duration of the injection schedule was only 12 weeks, which was significantly shorter than what was used in the present study. The duration of the study, however, is likely to have been too short because we were unable to obtain a follow-up measurement at 12 weeks after the last dose and therefore no assessment of long-term efficacy could be performed. There were no significant differences between the two groups in body composition parameters, although the patients on low doses showed a small increase in fat and muscle mass. In general, subjects on low doses of CPP-55 demonstrated the following changes to body composition parameters: body fat mass increased by 8.7 ± 2.6% over baseline; fat area decreased by 5.2 ± 8.3%. There were, however, no significant changes in lean mass or total body volume. Of all the variables measured, height, weight, height/weight ratio, and body composition increased significantly. These variables were significantly different from baseline values in both groups. Subjects on low doses of CPP-55 displayed statistically significant increases in total body size and in hip and spine mass (Fig.), both of which were significantly higher than baseline values. Compared with these values before starting the study at baseline, all subjects in the higher dose group (20 mg per day) displayed the following changes in total body size and in overall body volume: body weight, 5.2 ± 8.3 kg, and waist/hip circumference, 0.91 ± 0.07 cm and 0.79 ± 0.11 cm, respectively. We found that those injected with CPP-55 showed significantly greater increases in muscle mass and in lean muscle mass than those not receiving the drug. For example, for the 5-week, 2-dose extension study, weight loss was observed in patients in both study groups who did not receive CPP-55 [F = 17.0, P < 0.001; R2, 0.7%; see Materials and Methods ]. Fourteen subjects (23.9%) had a negative result for the CPP-55 efficacy assay after treatment at 16 weeks; 13 participants were able to complete the study. Of these, 12 (64%) experienced weight recovery after the treatment and 6 (36%) had an increase in lean mass. Although the results Similar articles: